![]() Some items can only be unlocked by finishing the 20+ endings in the game, but some of the best can be found during a first playthrough of the game. If you are lucky enough to unlock or stumble across certain items, though, your run is likely to go far better. The list of achievements, collectibles, and enemies is ever-growing. RELATED: Things You Didn't Know About The Binding Of IsaacĮach playthrough is a new experience, with every room and floor being randomly generated. ![]() The latest of them, Repentance, was released at the end of March of 2021 and has received many updates. The Binding of Isaac was released in 2011 and has undergone a complete re-release since, along with four expansions. From the creative mind of Edmund McMillen came a dungeon crawler inspired by The Legend of Zelda, loaded with religious, astrological, pop culture, and toilet humor references.
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